RGD Reference Report - Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency. - Rat Genome Database

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Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency.

Authors: Ponce, IT  Rezza, IG  Delgado, SM  Navigatore, LS  Bonomi, MR  Golini, RL  Gimenez, MS  Anzulovich, AC 
Citation: Ponce IT, etal., Biol Rhythm Res. 2012 Jul 1;43(4):351-372. Epub 2011 Aug 1.
RGD ID: 7257533
Pubmed: PMID:22984325   (View Abstract at PubMed)
PMCID: PMC3438693   (View Article at PubMed Central)
DOI: DOI:10.1080/09291016.2011.593847   (Journal Full-text)

Examples of hormonal phase-shifting of circadian gene expression began to emerge a few years ago. Vitamin A fulfills a hormonal function by binding of retinoic acid to its nuclear receptors, RARs and RXRs. We found retinoid- as well as clock-responsive sites on regulatory regions of Glutathione reductase (GR) and Glutathione peroxidase (GPx) genes. Interestingly, we observed retinoid receptors, as well as GSH, GR and GPx, display daily oscillating patterns in the rat liver. We also found that feeding animals with a vitamin A-free diet, dampened daily rhythms of RARalpha and RXRbeta mRNA, GR expression and activity, GSH, BMAL1 protein levels and locomotor activity. Differently, day-night oscillations of RXRalpha, GPx mRNA levels and activity and PER1 protein levels, were phase-shifted in the liver of vitamin A-deficient rats. These observations would emphasize the importance of micronutrient vitamin A in the modulation of biological rhythms of GSH and cellular redox state in liver.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to vitamin A  IEP 7257533 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsr  (glutathione-disulfide reductase)


Additional Information