RGD Reference Report - Interdependent effect of angiotensin-converting enzyme and platelet-activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy.

General

Interdependent effect of angiotensin-converting enzyme and platelet-activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy.
Authors:	Yoon, HJ Kim, H Kim, HL Lee, SG Zheng, SH Shin, JH Lim, CS Kim, S Lee, JS Lee, DS Kim, YS
Citation:	Yoon HJ, etal., Clin Genet. 2002 Aug;62(2):128-34.
RGD ID:	7257515
Pubmed:	PMID:12220450 (View Abstract at PubMed)
In order to investigate the interdependent action of the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene and polymorphism in exon 11 (C1136-->T; Ala379Val) of the platelet-activating factor acetylhydrolase (PAF-AH) gene, which encodes a functional antagonist of PAF, on the progression of immunoglobulin A (IgA) nephropathy, we analysed both polymorphisms in patients with primary IgA nephropathy, who were followed-up for longer than 3 years. During the follow-up (87.3 +/- 50.0 months), the disease progressed in 38 of the 191 patients (19.9%). The D allele of the ACE gene in the absence of the T allele of the PAF-AH gene did not affect the prognosis [odds ratio (OR), 3.6; 95% confidence interval (CI), 0.8-16.4] and neither did the T allele in the absence of the D allele (OR, 3.0; 95% CI, 0.4-24.2). However, the presence of both was a significant prognostic factor (OR, 6.6; 95% CI, 1.4-31.3). After adjusting for other risk factors, the presence of both proved to be an independent risk factor (OR, 4.5; 95% CI, 1.6-12.7). These results suggest that the interdependent effects of ACE and PAF-AH polymorphisms on the progression of IgA nephropathy might be more important than the effect of the individual polymorphisms.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
IgA glomerulonephritis	disease_progression	IAGP		7257515	DNA:polymorphism:intron:	RGD
IgA glomerulonephritis	disease_progression	ISO	ACE (Homo sapiens)	7257515; 7257515	DNA:polymorphism:intron:	RGD
IgA glomerulonephritis	disease_progression	IAGP		7257515	DNA:polymorphism:exon:	RGD
IgA glomerulonephritis	disease_progression	ISO	PLA2G7 (Homo sapiens)	7257515; 7257515	DNA:polymorphism:exon:	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ace (angiotensin I converting enzyme)

Pla2g7 (phospholipase A2 group VII)

Genes (Mus musculus)

Ace (angiotensin I converting enzyme)

Pla2g7 (phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma))

Genes (Homo sapiens)

ACE (angiotensin I converting enzyme)

PLA2G7 (phospholipase A2 group VII)

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Interdependent effect of angiotensin-converting enzyme and platelet-activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy.