RGD Reference Report - Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury. - Rat Genome Database

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Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury.

Authors: Zhang, L  Hu, R  Li, M  Li, F  Meng, H  Zhu, G  Lin, J  Feng, H 
Citation: Zhang L, etal., Neurol Sci. 2013 May;34(5):639-45. doi: 10.1007/s10072-012-1090-1. Epub 2012 Apr 27.
RGD ID: 7244386
Pubmed: PMID:22538758   (View Abstract at PubMed)
DOI: DOI:10.1007/s10072-012-1090-1   (Journal Full-text)

This study investigated whether deferoxamine (DFO), an iron chelator attenuates iron-induced toxicity in rats with traumatic brain injury. In this study, three groups of Sprague-Dawley rats (sham, injury and DFO groups) were examined. Rats were killed on day 28 after Morris water maze testing and brains perfused for either non-heme brain binding or hemosiderin staining. Western blotting was used to measure protein levels of ferritin, transferrin and transient receptor potential canonical channel 6 (TRPC6). In TBI rats, there was a significant increase in brain iron on day 28, ferritin L, ferritin H, transferrin and TRPC6 levels were all significantly elevated post-TB1. There were also deficits in spatial learning and memory; however, DFO administration attenuated these effects in TBI rats supporting the notion that DFO may reduce brain injury accentuated by iron overload.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOTf (Rattus norvegicus)7244386; 7244386 RGD 
Brain Injuries  IEP 7244386 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tf  (transferrin)

Genes (Mus musculus)
Trf  (transferrin)

Genes (Homo sapiens)
TF  (transferrin)


Additional Information