RGD Reference Report - Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. - Rat Genome Database

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Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.

Authors: Yoshida, T  Kato, K  Fujimaki, T  Yokoi, K  Oguri, M  Watanabe, S  Metoki, N  Yoshida, H  Satoh, K  Aoyagi, Y  Nishigaki, Y  Tanaka, M  Nozawa, Y  Yamada, Y 
Citation: Yoshida T, etal., Genomics. 2009 Mar;93(3):221-6. doi: 10.1016/j.ygeno.2008.11.001. Epub 2008 Dec 6.
RGD ID: 7243119
Pubmed: PMID:19056482   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ygeno.2008.11.001   (Journal Full-text)

The purpose of the present study was to identify genetic variants that confer susceptibility to chronic kidney disease (CKD) in Japanese individuals with metabolic syndrome. The study population comprised 2150 Japanese individuals with metabolic syndrome, including 411 subjects with CKD [estimated glomerular filtration rate (eGFR) <50 mL/min/1.73m(2)] and 1739 controls (eGFR >/=60 mL/min/1.73m(2)). The genotypes for 100 polymorphisms of 80 candidate genes were determined. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that nine polymorphisms of APOE, ABCA1, PTGS1, TNF, CPB2, AGTR1, OR13G1, and GNB3 were associated (P<0.05) with the prevalence of CKD. Among these polymorphisms, the -219G-->T polymorphism of APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic kidney disease  IAGP 7243119DNA:polymorphism:cds :p.A147T(rs3742264)(human)RGD 
chronic kidney disease  ISOCPB2 (Homo sapiens)7243119; 7243119DNA:polymorphism:cds :p.A147T(rs3742264)(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cpb2  (carboxypeptidase B2)

Genes (Mus musculus)
Cpb2  (carboxypeptidase B2)

Genes (Homo sapiens)
CPB2  (carboxypeptidase B2)


Additional Information