RGD Reference Report - Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation. - Rat Genome Database

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Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation.

Authors: Villalonga, N  Martinez-Marmol, R  Roura-Ferrer, M  David, M  Valenzuela, C  Soler, C  Felipe, A 
Citation: Villalonga N, etal., Biochim Biophys Acta. 2008 May;1783(5):728-36. doi: 10.1016/j.bbamcr.2008.01.001. Epub 2008 Jan 12.
RGD ID: 7242757
Pubmed: PMID:18230363   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbamcr.2008.01.001   (Journal Full-text)

Voltage-dependent K(+) channels (Kv) are involved in the proliferation of many types of cells, but the mechanisms by which their activity is related to cell growth remain unclear. Kv antagonists inhibit the proliferation of mammalian cells, which is of physiological relevance in skeletal muscle. Although myofibres are terminally differentiated, some resident myoblasts may re-enter the cell cycle and proliferate. Here we report that the expression of Kv1.5 is cell-cycle dependent during myoblast proliferation. In addition to Kv1.5 other Kv, such as Kv1.3, are also up-regulated. However, pharmacological evidence mainly implicates Kv1.5 in myoblast growth. Thus, the presence of S0100176, a Kv antagonist, but not margatoxin and dendrotoxin, led to cell cycle arrest during the G(1)-phase. The use of selective cell cycle blockers showed that Kv1.5 was transiently accumulated during the early G(1)-phase. Furthermore, while myoblasts treated with S0100176 expressed low levels of cyclin A and D(1), the expression of p21(cip-1) and p27(kip1), two cyclin-dependent kinase inhibitors, increased. Our results indicate that the cell cycle-dependent expression of Kv1.5 is involved in skeletal muscle cell proliferation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Kcna5  (potassium voltage-gated channel subfamily A member 5)


Additional Information