RGD Reference Report - Effects of periodontitis on aortic insulin resistance in an obese rat model. - Rat Genome Database

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Effects of periodontitis on aortic insulin resistance in an obese rat model.

Authors: Ekuni, D  Tomofuji, T  Irie, K  Kasuyama, K  Umakoshi, M  Azuma, T  Tamaki, N  Sanbe, T  Endo, Y  Yamamoto, T  Nishida, T  Morita, M 
Citation: Ekuni D, etal., Lab Invest. 2010 Mar;90(3):348-59. doi: 10.1038/labinvest.2009.141. Epub 2010 Jan 11.
RGD ID: 7240508
Pubmed: PMID:20065945   (View Abstract at PubMed)
DOI: DOI:10.1038/labinvest.2009.141   (Journal Full-text)

The combination of obesity and its associated risk factors, such as insulin resistance and inflammation, results in the development of atherosclerosis. However, the effects of periodontitis on atherosclerosis in an obese body remain unclear. The aim of the study was to investigate the effects of ligature-induced periodontitis in Zucker fatty rats on initiation of atherosclerosis by evaluating aortic insulin resistance. Zucker fatty rats (n=24) were divided into two groups. In the periodontitis group, periodontitis was ligature-induced for 4 weeks, whereas the control group was left unligated. After the 4-week experimental period, descending aorta was used for measuring the levels of lipid deposits, immunohistochemical analysis, and evaluation of gene expression. Levels of serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and insulin were also measured. Rats in the periodontitis group had significantly enhanced lipid deposits in the aorta, but not in the control group. Expression of suppressor of cytokine signaling 3, vascular cell adhesion molecule 1, reactive oxygen species, nitrotyrosine, and endothelin-1 in the periodontitis group was more intense than that in the control group. Significantly decreased levels of phosphatidylinositol 3-kinase (Pi3k) catalytic beta-polypeptide (Pi3kcb), Pi3kp85, and insulin receptor substrate 1 and 2 were observed in the periodontitis group. Levels of serum CRP and TNF-alpha were significantly increased in the periodontitis group. Under insulin-stimulated conditions, aorta in the periodontitis group altered the Akt phosphorylation. Periodontitis in obesity induced the initial stage of atherosclerosis and disturbed aortic insulin signaling.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
periodontitis  ISOVcam1 (Rattus norvegicus)7240508; 7240508associated with obesity and protein:increased expression:aorta:RGD 
periodontitis  IEP 7240508associated with obesity and protein:increased expression:aorta:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vcam1  (vascular cell adhesion molecule 1)

Genes (Mus musculus)
Vcam1  (vascular cell adhesion molecule 1)

Genes (Homo sapiens)
VCAM1  (vascular cell adhesion molecule 1)


Additional Information