RGD Reference Report - Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular gland. - Rat Genome Database

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Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular gland.

Authors: Ueda, K  Shimizu, O  Oka, S  Saito, M  Hide, M  Matsumoto, M 
Citation: Ueda K, etal., Int J Oral Maxillofac Surg. 2009 Jan;38(1):79-84. doi: 10.1016/j.ijom.2008.11.004. Epub 2008 Dec 18.
RGD ID: 7205460
Pubmed: PMID:19097859   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ijom.2008.11.004   (Journal Full-text)

The aim of this study was to determine the localization of tenascin-C, fibronectin and collagen types III and IV during regeneration of the rat submandibular gland. After 7 days' obstruction, the regenerating glands were collected at days 0, 1, 3, 5, 7, 11 and 14 after duct release to study regeneration. Immunohistochemical staining revealed that tenascin-C was strongly expressed in the epithelial cells of duct-acinar structures at days 0-3, and down-regulated in its expression from day 5 to 11, though weak expression was detected in the intercalated duct and acinar cells of the normal gland. Strong labeling of fibronectin was detected around duct-acinar structures during days 0-3 of regeneration. Type IV collagen was expressed strongly in the thickened basement membrane of acinar cells and duct-acinar structures during days 0-3, but weakly around large ducts, though type III collagen was expressed at consistent levels. These findings suggest that tenascin-C and fibronectin affect only the duct-acinar structures, and type IV but not type III collagen is involved in the regeneration of acinar cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
submandibular gland disease  ISOFn1 (Rattus norvegicus)7205460; 7205460 RGD 
submandibular gland disease  IEP 7205460 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fn1  (fibronectin 1)

Genes (Mus musculus)
Fn1  (fibronectin 1)

Genes (Homo sapiens)
FN1  (fibronectin 1)


Additional Information