RGD Reference Report - Calcium signalling remodelling and disease. - Rat Genome Database

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Calcium signalling remodelling and disease.

Authors: Berridge, MJ 
Citation: Berridge MJ Biochem Soc Trans. 2012 Apr;40(2):297-309. doi: 10.1042/BST20110766.
RGD ID: 7204690
Pubmed: PMID:22435804   (View Abstract at PubMed)
DOI: DOI:10.1042/BST20110766   (Journal Full-text)

A wide range of Ca2+ signalling systems deliver the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. Release of Ca2+ by InsP3 (inositol 1,4,5-trisphosphate) plays a central role in many of these signalling systems. Ongoing transcriptional processes maintain the integrity and stability of these cell-specific signalling systems. However, these homoeostatic systems are highly plastic and can undergo a process of phenotypic remodelling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease.

Objects Annotated

Genes (Rattus norvegicus)
Cnga1  (cyclic nucleotide gated channel subunit alpha 1)
Cnga2  (cyclic nucleotide gated channel subunit alpha 2)
Cnga3  (cyclic nucleotide gated channel subunit alpha 3)
Cnga4  (cyclic nucleotide gated channel subunit alpha 4)
Cngb1  (cyclic nucleotide gated channel subunit beta 1)
Cngb3  (cyclic nucleotide gated channel subunit beta 3)

Genes (Mus musculus)
Cnga1  (cyclic nucleotide gated channel alpha 1)
Cnga2  (cyclic nucleotide gated channel alpha 2)
Cnga3  (cyclic nucleotide gated channel alpha 3)
Cnga4  (cyclic nucleotide gated channel alpha 4)
Cngb1  (cyclic nucleotide gated channel beta 1)
Cngb3  (cyclic nucleotide gated channel beta 3)

Genes (Homo sapiens)
CNGA1  (cyclic nucleotide gated channel subunit alpha 1)
CNGA2  (cyclic nucleotide gated channel subunit alpha 2)
CNGA3  (cyclic nucleotide gated channel subunit alpha 3)
CNGA4  (cyclic nucleotide gated channel subunit alpha 4)
CNGB1  (cyclic nucleotide gated channel subunit beta 1)
CNGB3  (cyclic nucleotide gated channel subunit beta 3)


Additional Information