RGD Reference Report - Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy. - Rat Genome Database

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Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy.

Authors: Shinzawa, M  Yamamoto, R  Nagasawa, Y  Shoji, T  Obi, Y  Namba, T  Kitamura, H  Kaneko, T  Okada, N  Iwatani, H  Yamauchi, A  Tsubakihara, Y  Imai, E  Isaka, Y  Rakugi, H 
Citation: Shinzawa M, etal., Clin Exp Nephrol. 2012 Apr;16(2):250-8. doi: 10.1007/s10157-011-0553-7. Epub 2011 Nov 11.
RGD ID: 7204129
Pubmed: PMID:22072187   (View Abstract at PubMed)
DOI: DOI:10.1007/s10157-011-0553-7   (Journal Full-text)

BACKGROUND: Hypertension, which is affected by genetic and environmental factors, is one of the major risk factors for chronic kidney disease. Identification of the genetic factor contributing to hypertension in patients with chronic kidney disease may potentially refine a therapeutic strategy. METHODS: In the present multicenter cross-sectional study, 240 patients were eligible (aged 15-50 years with urinary protein >/=0.25 g/day) out of 429 patients who were diagnosed as having immunoglobulin (Ig) A nephropathy (IgAN) by renal biopsy between 1990 and 2005 and enrolled in our previous study, PREDICT-IgAN. The outcome was hypertension defined as >/=140 and/or >/=90 mmHg of systolic and diastolic blood pressure and/or use of antihypertensives at renal biopsy. We assessed associations between hypertension and 28 polymorphisms with the frequency of minor genotype >/=10% among 100 atherosclerosis-related polymorphisms using the Chi-squared test in dominant and recessive models. We identified polymorphisms associated with hypertension in multivariate logistic regression models. RESULTS: Baseline characteristics: hypertension 36.3%. Among 28 polymorphisms, the Chi-squared test revealed that CD14 (-159CC vs CT/TT, P = 0.03) and ACE (DD vs DI/II, P = 0.03) were significantly associated with hypertension after Bonferroni correction. Multivariate logistic regression models revealed that CD14 -159CC [vs CT/TT, odds ratio (OR) 3.58 (95% confidence interval (CI) 1.66-7.63)] and ACE DD [vs DI/II, OR 4.41 (95% CI 1.80-10.8), P = 0.001] were independently associated with hypertension. CONCLUSIONS: CD14 C-159T and ACE I/D contributed to hypertension in patients with IgAN.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 7204129associated with Glomerulonephritis more ...RGD 
hypertension  ISOCD14 (Homo sapiens)7204129; 7204129associated with Glomerulonephritis more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd14  (CD14 molecule)

Genes (Mus musculus)
Cd14  (CD14 antigen)

Genes (Homo sapiens)
CD14  (CD14 molecule)


Additional Information