RGD Reference Report - Mapping of glutathione transferase (GST) genes in the rat. - Rat Genome Database

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Mapping of glutathione transferase (GST) genes in the rat.

Authors: Klinga-Levan, K  Andersson, A  Hanson, C  Ridderstrom, M  Stenberg, G  Mannervik, B  Vajdy, M  Szpirer, J  Szpirer, C  Levan, G 
Citation: Klinga-Levan K, etal., Hereditas 1993;119(3):285-96.
RGD ID: 70479
Pubmed: PMID:8144363   (View Abstract at PubMed)

Glutathione transferases (GST) make up a large group of related enzymes in mammalian tissues. The enzyme molecules are dimeric and at least 13 different subunits occur in the rat. Each subunit appears to be coded for by a distinct gene, and thus there is a large GST gene family in the rat. Recently, there have been several reports of the mapping of rat GST genes. In the present communication we confirm the previous assignments and extend the data with the mapping to rat chromosome 2 of a previously unmapped GST gene (Gstm1), and with the regional mapping of seven Gstp genes. These mappings provide further evidence for conservation of syntenic gene relationships among mammals. The human homologs of Gstm1 map to chromosome 1, and belong to a group of 9 genes that show conserved synteny on rat chromosome 2. The corresponding murine genes in most cases map to mouse chromosome 3. Similarly, the human homolog of Gstp maps to chromosome 11, and is one of 10 genes that exhibit conserved synteny on rat chromosome 1. The corresponding mouse genes map to mouse chromosome 7. Previously only one gene on rat chromosome 8 had a human homolog on chromosome 6, and rat Gsta1 is the second instance. Based on these mappings it appears that a new group of genes will exhibit conserved synteny on rat chromosome 8, human chromosome 6 and mouse chromosome 9. Interestingly, each of the three groups of conserved synteny seems to span the region across the centromeres of the human chromosomes.

Objects referenced in this article
Gene Acadm acyl-Coenzyme A dehydrogenase, medium chain Mus musculus
Gene Amy1 amylase 1, salivary Mus musculus
Gene Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide Mus musculus
Gene Calca calcitonin/calcitonin-related polypeptide, alpha Mus musculus
Gene Igf2 insulin-like growth factor 2 Mus musculus
Gene Nras neuroblastoma ras oncogene Mus musculus
Gene Pklr pyruvate kinase liver and red blood cell Mus musculus
Gene Pth parathyroid hormone Mus musculus
Gene Gsta1 glutathione S-transferase alpha 1 Rattus norvegicus
Gene Gstm1 glutathione S-transferase mu 1 Rattus norvegicus
Gene Gstp-ps1 glutathione-S-transferase, pi type, pseudogene 1 Rattus norvegicus
Gene Gstp1 glutathione S-transferase pi 1 Rattus norvegicus

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