RGD Reference Report - Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. - Rat Genome Database

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Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats.

Authors: Cicila, GT  Choi, C  Dene, H  Lee, SJ  Rapp, JP 
Citation: Cicila GT, etal., Mamm Genome 1999 Feb;10(2):112-6.
RGD ID: 69705
Pubmed: PMID:9922389   (View Abstract at PubMed)

Interval mapping was used to identify putative quantitative trait loci (QTL) for blood pressure and cardiac mass on Chromosome (Chr) 3 in F1(S x R) x S population of 150 rats raised on an 8% NaCl diet. Two genetic markers 95.7 cM apart, D3Wox3 and D3Mco5 (tightly linked to Edn3), showed "suggestive" linkage to blood pressure (LOD = 2.0 and 1.8 respectively). In addition, D3Wox3 showed "suggestive" linkage to heart weight (LOD = 2.5), and D3Mco5 showed "suggestive" linkage to body weight-adjusted heart weight (LOD = 2.1). Congenic rats (designated S.R-Edn3) were constructed by introgressing the R-rat Edn3 allele (and flanking loci) into the S strain. On a 2% NaCl diet, S.R-Edn3 rats had lower blood pressure (21.4 mm Hg, P = 0. 0005) and heart weight (59 mg, P = 0.0038) compared with S rats, confirming the existence of a blood pressure QTL on Chr 3 near Edn3 even though QTL linkage analysis of blood pressure did not achieve stringent statistical criteria for significance. The results of the congenic experiment and the large distance between the two putative QTL suggest the presence of at least two independent blood pressure/cardiac mass QTL detectable on Chr 3 in the Dahl rat model of genetic hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IDA 69705; 69705 RGD 
Hypotension inducedIAGPcontrolled sodium content diet69705compared to SS/JrRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


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Objects Annotated

QTLs
Bp163  (Blood pressure QTL 163)
Cm13  (Cardiac mass QTL 13)
Cm14  (Cardiac mass QTL 14)

Strains
SR/Jr  (Salt Resistant)
SS.SR-(D3Mco19-D3Mco5)/Jr  (NA)
SS/Jr  (Salt Sensitive)


Additional Information