RGD Reference Report - Scavenger receptor class B type I: a multifunctional receptor. - Rat Genome Database

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Scavenger receptor class B type I: a multifunctional receptor.

Authors: Valacchi, G  Sticozzi, C  Lim, Y  Pecorelli, A 
Citation: Valacchi G, etal., Ann N Y Acad Sci. 2011 Jul;1229:E1-7. doi: 10.1111/j.1749-6632.2011.06205.x.
RGD ID: 6904153
Pubmed: PMID:22239457   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1749-6632.2011.06205.x   (Journal Full-text)

The scavenger receptor class B type I (SR-B1) plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR-B1 is a high-density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR-B1 does this is unclear. Other than its role as an HDL receptor, SR-B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in the uptake of lipid soluble vitamins, such as vitamin E and carotenoids. In this short review, we have summarized the biological aspects to which SR-B1 has been thus far associated.


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