RGD Reference Report - The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.

Authors: Von Lintig, J  Kiser, PD  Golczak, M  Palczewski, K 
Citation: von Lintig J, etal., Trends Biochem Sci. 2010 Jul;35(7):400-10. Epub 2010 Feb 24.
RGD ID: 6903223
Pubmed: PMID:20188572   (View Abstract at PubMed)
PMCID: PMC2891588   (View Article at PubMed Central)
DOI: DOI:10.1016/j.tibs.2010.01.005   (Journal Full-text)

Recently, much progress has been made in elucidating the chemistry and metabolism of retinoids and carotenoids, as well as the structures of processing proteins related to vision. Carotenoids and their retinoid metabolites are isoprenoids, so only a limited number of chemical transformations are possible, and just a few of these occur naturally. Although there is an intriguing evolutionary conservation of the key components involved in the production and recycling of chromophores, these genes have also adapted to the specific requirements of insect and vertebrate vision. These 'ancestral footprints' in animal genomes bear witness to the common origin of the chemistry of vision, and will further stimulate research across evolutionary boundaries.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
retinoid cycle metabolic pathway   TAS 6903223 RGD 
retinoid cycle metabolic pathway   ISORLBP1 (Homo sapiens)6903223; 6903223 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Rlbp1  (retinaldehyde binding protein 1)

Genes (Mus musculus)
Rlbp1  (retinaldehyde binding protein 1)

Genes (Homo sapiens)
RLBP1  (retinaldehyde binding protein 1)


Additional Information