RGD Reference Report - Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. - Rat Genome Database

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Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.

Authors: Pravenec, M  Landa, V  Zidek, V  Musilova, A  Kren, V  Kazdova, L  Aitman, TJ  Glazier, AM  Ibrahimi, A  Abumrad, NA  Qi, N  Wang, JM  St Lezin, EM  Kurtz, TW 
Citation: Pravenec M, etal., Nat Genet 2001 Feb;27(2):156-8.
RGD ID: 68930
Pubmed: PMID:11175782   (View Abstract at PubMed)
DOI: DOI:10.1038/84777   (Journal Full-text)

Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Insulin Resistance  ISOCd36 (Rattus norvegicus)68930; 68930 RGD 
Insulin Resistance  IMP 68930 RGD 
Insulin Resistance inducedIAGPinsulin and controlled fructose content diet68930compared to SHR-Tg(Ef1a-Cd36)19Ipcv and SHR-Tg(Ef1a-Cd36)10IpcvRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
fatty acid metabolic process  IMP 68930 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased circulating free fatty acids level  IMP 68930 RGD 
decreased circulating free fatty acids level inducedIAGPcontrolled fructose content diet68930; 68930compared to SHR/OlaIpcvRGD 
improved glucose tolerance inducedIAGPcontrolled fructose content diet and glucose68930; 68930compared to SHR/OlaIpcvRGD 
Objects Annotated

Genes (Rattus norvegicus)
Cd36  (CD36 molecule)

Genes (Mus musculus)
Cd36  (CD36 molecule)

Genes (Homo sapiens)
CD36  (CD36 molecule (CD36 blood group))


Additional Information