RGD Reference Report - Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism. - Rat Genome Database

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Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism.

Authors: Okumura, N  Seki, T  Ariga, T 
Citation: Okumura N, etal., Biosci Biotechnol Biochem. 2007 Jun;71(6):1542-9.
RGD ID: 6484147
Pubmed: PMID:17587687   (View Abstract at PubMed)
DOI: DOI:10.1271/bbb.70126   (Journal Full-text)

Plasminogen and plasminogen activators play important roles in liver regeneration. Previously, we found that plasminogen potentiates hepatocyte proliferation in the primary culture of rat hepatocytes. Here, we examined how exogenous plasminogen affects the downstream events leading to cell proliferation. The addition of plasminogen to hepatocytes increased urokinase-type plasminogen activator (uPA) activity, but did not affect matrix metalloproteinase (MMP)-9 or MMP-2 activities. To increase uPA activity, plasminogen was required to bind the hepatocyte surface through the lysine-binding site of plasminogen molecule, but neither uPA mRNA nor uPA receptor (uPAR) mRNA was affected by the exogenous plasminogen. In addition, treatment of hepatocytes with an uPA inhibitor, p-aminobenzamidine, inhibited the plasminogen-induced and even EGF-induced hepatocyte proliferation. These results suggest that plasminogen-related control of hepatocyte proliferation is exerted topically by producing a hyperfibrinolytic state on the cellular surface involving the activation of uPA.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of hepatocyte proliferation  IMP 6484147 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plau  (plasminogen activator, urokinase)


Additional Information