RGD Reference Report - The expression of fibrinolytic components in chronic paranasal sinus disease. - Rat Genome Database

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The expression of fibrinolytic components in chronic paranasal sinus disease.

Authors: Sejima, T  Holtappels, G  Bachert, C 
Citation: Sejima T, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):1-6.
RGD ID: 6483796
Pubmed: PMID:21711960   (View Abstract at PubMed)
DOI: DOI:10.2500/ajra.2011.25.3537   (Journal Full-text)

BACKGROUND: Fibrinolytic components, their receptors, and inhibitors are considered to play an important role in inflammation and tissue remodeling including chronic rhinosinusitis (CRS). To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS. METHODS: Sinonasal mucosa samples from 12 patients with CRS without nasal polyp (CRSsNP), 14 patients with CRS with nasal polyp (CRSwNP), and 12 control patients were prepared. By immunohistochemistry and ELISA, samples were studied with respect to urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), plasminogen activator inhibitor-1 (PAI-1) and key mediators in sinus disease, TGF-beta1 and eosinophil cationic protein (ECP). RESULTS: uPA- or uPAR-positive inflammatory cells were increased in CRSwNP compared to controls and CRSsNP, whereas PAI-1-positive cells were increased in CRSsNP compared to CRSwNP and controls. ELISA measurements revealed that uPAR concentrations were increased in both CRSsNP (16.1 ng/mL; 10.4-22.9; p < 0.05) and CRSwNP (20.8 ng/mL; 9.62-25.9; p < 0.01) compared to controls (8.7 ng/mL; 7.9-12.9), and PAI-1 concentrations were increased in CRSsNP (198.8 ng/mL; 147.4-234.1) compared to controls (107.3 ng/mL; 92.6-175.3; p < 0.01) and CRSwNP (113.5 ng/mL; 105.1-193.5; p < 0.05). Moreover, the concentrations of TGF-beta1 correlated with PAI-1 in CRSsNP, and ECP correlated with uPAR protein in CRSwNP. CONCLUSION: Fibrinolytic components were highly expressed in CRSwNP compared to normal controls, whereas the inhibiting protein was up-regulated in CRSsNP. Furthermore, correlations between the expressions of fibrinolytic components and key mediators in CRS were found.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Nasal Polyps  IEP 6483796associated with SinusitisRGD 
Nasal Polyps  ISOPLAUR (Homo sapiens)6483796; 6483796associated with SinusitisRGD 
Rhinosinusitis  IEP 6483796protein:increased expression:nasal mucosa (human)RGD 
Rhinosinusitis  ISOSERPINE1 (Homo sapiens)6483796; 6483796protein:increased expression:nasal mucosa (human)RGD 
sinusitis  IEP 6483796; 6483796 RGD 
sinusitis  ISOPLAU (Homo sapiens)6483796; 6483796 RGD 
sinusitis  ISOPLAUR (Homo sapiens)6483796; 6483796 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plau  (plasminogen activator, urokinase)
Plaur  (plasminogen activator, urokinase receptor)
Serpine1  (serpin family E member 1)

Genes (Mus musculus)
Plau  (plasminogen activator, urokinase)
Plaur  (plasminogen activator, urokinase receptor)
Serpine1  (serine (or cysteine) peptidase inhibitor, clade E, member 1)

Genes (Homo sapiens)
PLAU  (plasminogen activator, urokinase)
PLAUR  (plasminogen activator, urokinase receptor)
SERPINE1  (serpin family E member 1)


Additional Information