RGD Reference Report - OS-9: another piece in the HIF complex story.

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OS-9: another piece in the HIF complex story.
Authors:	Flashman, E McDonough, MA Schofield, CJ
Citation:	Flashman E, etal., Mol Cell. 2005 Feb 18;17(4):472-3.
RGD ID:	6483504
Pubmed:	PMID:15721249 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.molcel.2005.02.001 (Journal Full-text)
In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involved in the hypoxic response (Baek et al., 2005).

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.