RGD Reference Report - Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis. - Rat Genome Database

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Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis.

Authors: Vargas-Alarcon, G  Gamboa, R  Zuniga, J  Fragoso, JM  Hernandez-Pacheco, G  Londono, J  Pacheco-Tena, C  Cardiel, MH  Granados, J  Burgos-Vargas, R 
Citation: Vargas-Alarcon G, etal., Hum Immunol. 2004 Dec;65(12):1437-42.
RGD ID: 6483462
Pubmed: PMID:15603870   (View Abstract at PubMed)
DOI: DOI:10.1016/j.humimm.2004.09.007   (Journal Full-text)

To evaluate the role of LMP (low molecular weight protein) genes as susceptibility markers for spondyloarthritis (SpA), LMP gene polymorphisms were analyzed in 223 Mexican patients with SpA (81 undifferentiated SpA [U-SpA], 117 with ankylosing spondylitis [AS], 25 with reactive arthritis) and in 139 ethnically matched healthy individuals. LMP genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The LMP2 and LMP7 allele frequencies were similar in patients and healthy controls. Genotype analysis revealed an increased frequency of LMP2 R/R genotype in the whole group of SpA (pC = 0.003, OR = 2.06, 95%CI = 1.3-3.25) and in the clinical subgroups of AS (pC = 0.039, OR = 1.88, 95%CI = 1.1-3.22) and U-SpA (pC = 0.003, OR = 2.56, 95%CI = 1.37-4.8) compared with healthy controls. Analysis in the LMP7 did not reveal significant differences in patients and healthy controls. The HLA-B27-negative AS subgroup also showed an increased frequency of LMP2 R/R genotype (pC = 0.027, OR = 4.81, 95%CI = 1.21-22.13). The LMP2-R/R AS patients were younger than LMP2-H/R and H/H patients at onset of the disease (16.0 +/- 6.8 years for R/R, 22.0 +/- 11.2 years for H/R and 28.6 +/- 10.9 years for H/H) (p < 0.05). The data suggest that, besides HLA-B27, LMP2 genotypes are also involved in the genetic susceptibility to develop AS in Mexicans. Furthermore, the age at onset of this disease might also be influenced by genotypes of this gene.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spondylarthritis  IAGP 6483462 RGD 
Spondylarthritis  ISOPSMB9 (Homo sapiens)6483462; 6483462 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Psmb9  (proteasome 20S subunit beta 9)

Genes (Mus musculus)
Psmb9  (proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2))

Genes (Homo sapiens)
PSMB9  (proteasome 20S subunit beta 9)


Additional Information