RGD Reference Report - Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. - Rat Genome Database

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Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Authors: Brenu, EW  Van Driel, ML  Staines, DR  Ashton, KJ  Ramos, SB  Keane, J  Klimas, NG  Marshall-Gradisnik, SM 
Citation: Brenu EW, etal., J Transl Med. 2011 May 28;9:81.
RGD ID: 6482801
Pubmed: PMID:21619669   (View Abstract at PubMed)
PMCID: PMC3120691   (View Article at PubMed Central)
DOI: DOI:10.1186/1479-5876-9-81   (Journal Full-text)

BACKGROUND: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of life, difficult clinical management and high costs to the health care system. To date there is no proven pathomechanism to satisfactorily explain this disorder. Studies have identified abnormalities in immune function but these data are inconsistent. We investigated the profile of markers of immune function (including novel markers) in CFS/ME patients. METHODS: We included 95 CFS/ME patients and 50 healthy controls. All participants were assessed on natural killer (NK) and CD8(+) T cell cytotoxic activities, Th1 and Th2 cytokine profile of CD4(+) T cells, expression of vasoactive intestinal peptide receptor 2 (VPACR2), levels of NK phenotypes (CD56(bright) and CD56(dim)) and regulatory T cells expressing FoxP3 transcription factor. RESULTS: Compared to healthy individuals, CFS/ME patients displayed significant increases in IL-10, IFN-gamma, TNF-alpha, CD4(+)CD25(+) T cells, FoxP3 and VPACR2 expression. Cytotoxic activity of NK and CD8(+) T cells and NK phenotypes, in particular the CD56(bright) NK cells were significantly decreased in CFS/ME patients. Additionally granzyme A and granzyme K expression were reduced while expression levels of perforin were significantly increased in the CFS/ME population relative to the control population. These data suggest significant dysregulation of the immune system in CFS/ME patients. CONCLUSIONS: Our study found immunological abnormalities which may serve as biomarkers in CFS/ME patients with potential for an application as a diagnostic tool.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic fatigue syndrome  IEP 6482801 RGD 
chronic fatigue syndrome  ISOPRF1 (Homo sapiens)6482801; 6482801 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prf1  (perforin 1)

Genes (Mus musculus)
Prf1  (perforin 1 (pore forming protein))

Genes (Homo sapiens)
PRF1  (perforin 1)


Additional Information