RGD Reference Report - Met-11 of HLA class II DP alpha 1 first domain associated with onchocerciasis. - Rat Genome Database

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Met-11 of HLA class II DP alpha 1 first domain associated with onchocerciasis.

Authors: Meyer, CG  Schnittger, L  May, J 
Citation: Meyer CG, etal., Exp Clin Immunogenet. 1996;13(1):12-9.
RGD ID: 6480649
Pubmed: PMID:8854084   (View Abstract at PubMed)

Human infection with the pathogenic tissue nematode Onchocerca volvulus may result in a spectrum of clinical manifestations or in a putatively immune condition. A methionine at amino acid position 11 of the HLA class II DP alpha 1 chain correlates with the occurring disease after infection (relative risk 3.3). The alternative alanine at position 11 is, conversely, associated with protection from disease ("relative protection' 3.5). DPA1*0301 is associated with the localized form of disease after O. volvulus infection.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
onchocerciasis  ISOHLA-DPA1 (Homo sapiens)6480649; 6480649 RGD 
onchocerciasis  IAGP 6480649 RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ha  (RT1 class II, locus Ha)

Genes (Mus musculus)
H2-Pa  (histocompatibility 2, P region alpha locus)

Genes (Homo sapiens)
HLA-DPA1  (major histocompatibility complex, class II, DP alpha 1)


Additional Information