RGD Reference Report - No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population. - Rat Genome Database

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No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population.

Authors: Ikeda, M  Ozaki, N  Yamanouchi, Y  Suzuki, T  Kitajima, T  Kinoshita, Y  Inada, T  Iwata, N 
Citation: Ikeda M, etal., Schizophr Res. 2007 Mar;91(1-3):22-6. Epub 2007 Feb 14.
RGD ID: 6480430
Pubmed: PMID:17303389   (View Abstract at PubMed)
DOI: DOI:10.1016/j.schres.2006.12.020   (Journal Full-text)

Postmortem studies regarding schizophrenia revealed altered expression of genes related to gamma-amino butyric acid neurotransmission system. One of the most consistent findings is the reduced level of 67 kDa glutamic acid decarboxylase isoform (GAD(67)). Moreover, several studies reported positive associations between the GAD(67) gene (GAD1) and schizophrenia. These reasons, motivated us to carry out replication study regarding association between GAD1 (fourteen tagging SNPs) and schizophrenia in Japanese population (562 schizophrenic patients and 470 controls). However we couldn't confirm significant association that had been previously reported. Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia no_associationIAGP 6480430DNA:snp(s)::Japanese populationRGD 
schizophrenia no_associationISOGAD1 (Homo sapiens)6480430; 6480430DNA:snp(s)::(human - Japanese population)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gad1  (glutamate decarboxylase 1)

Genes (Mus musculus)
Gad1  (glutamate decarboxylase 1)

Genes (Homo sapiens)
GAD1  (glutamate decarboxylase 1)


Additional Information