RGD Reference Report - Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator messenger ribonucleic acids and proteins in rat and human testis. - Rat Genome Database

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Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator messenger ribonucleic acids and proteins in rat and human testis.

Authors: Schultz, R  Suominen, J  Varre, T  Hakovirta, H  Parvinen, M  Toppari, J  Pelto-Huikko, M 
Citation: Schultz R, etal., Endocrinology 2003 Mar;144(3):767-76.
RGD ID: 634668
Pubmed: PMID:12586752   (View Abstract at PubMed)
DOI: DOI:10.1210/en.2002-220642   (Journal Full-text)

Dioxins, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), use the aryl hydrocarbon receptor (AHR)/aryl hydrocarbon receptor nuclear translocator (ARNT) receptor complex to mediate their toxic actions. In addition to interaction with environmental pollutants, several transcription factors, steroid receptors, and growth factors are capable interacting with the AHR/ARNT complex, which suggests a constitutive role for the receptor complex. The testis has been reported to be among the most sensitive organs to TCDD exposure. Our experiments revealed a complex distribution of AHR and ARNT mRNAs and proteins in rat and human testis. AHR and ARNT immunoreactivities could be detected in the nuclei of interstitial and tubular cells. The incubation of seminiferous tubules in a serum-free culture medium resulted in up-regulation of AHR mRNA, which could be depressed by adding FSH to the culture medium. Furthermore, the incubation of tubular segments with a solution of 1 or 100 nM TCDD resulted in a 2- to 3-fold increase in apoptotic cells. Thus, up-regulation of AHR in cultured tubular segments and consecutive depression by FSH suggest a role for AHR in controlled cell death during spermatogenesis. We suggest that AHR and ARNT mediate effects by direct action on testicular cells in the rat and human testis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to toxic substance  NAS 634668 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Arnt  (aryl hydrocarbon receptor nuclear translocator)

Objects referenced in this article
Gene AHR aryl hydrocarbon receptor Homo sapiens
Gene ARNT aryl hydrocarbon receptor nuclear translocator Homo sapiens
Gene Ahr aryl-hydrocarbon receptor Mus musculus
Gene Arnt aryl hydrocarbon receptor nuclear translocator Mus musculus
Gene Ahr aryl hydrocarbon receptor Rattus norvegicus

Additional Information