RGD Reference Report - Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. - Rat Genome Database

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Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons.

Authors: Angelastro, JM  Ignatova, TN  Kukekov, VG  Steindler, DA  Stengren, GB  Mendelsohn, C  Greene, LA 
Citation: Angelastro JM, etal., J Neurosci 2003 Jun 1;23(11):4590-600.
RGD ID: 634608
Pubmed: PMID:12805299   (View Abstract at PubMed)
PMCID: PMC6740805   (View Article at PubMed Central)

An important milestone in brain development is the transition of neuroprogenitor cells to postmitotic neurons. We report that the bZIP transcription factor ATF5 plays a major regulatory role in this process. In developing brain ATF5 expression is high within ventricular zones containing neural stem and progenitor cells and is undetectable in postmitotic neurons. In attached clonal neurosphere cultures ATF5 is expressed by neural stem/progenitor cells and is undetectable in tau-positive neurons. In PC12 cell cultures nerve growth factor (NGF) dramatically downregulates endogenous ATF5 protein and transcripts, whereas exogenous ATF5 suppresses NGF-promoted neurite outgrowth. Such inhibition requires the repression of CRE sites. In contrast, loss of function conferred by dominant-negative ATF5 accelerates NGF-promoted neuritogenesis. Exogenous ATF5 also suppresses, and dominant-negative ATF5 and a small-interfering RNA targeted to ATF5 promote, neurogenesis by cultured nestin-positive telencephalic cells. These findings indicate that ATF5 blocks the differentiation of neuroprogenitor cells into neurons and must be downregulated to permit this process to occur.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of neurogenesis  IDA 634608 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DNA-binding transcription factor activity  TAS 634608 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atf5  (activating transcription factor 5)


Additional Information