RGD Reference Report - Identification of a new synaptic vesicle protein 2B mRNA transcript which is up-regulated in neurons by amyloid beta peptide fragment (1-42). - Rat Genome Database

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Identification of a new synaptic vesicle protein 2B mRNA transcript which is up-regulated in neurons by amyloid beta peptide fragment (1-42).

Authors: Heese, K  Nagai, Y  Sawada, T 
Citation: Heese K, etal., Biochem Biophys Res Commun 2001 Dec 21;289(5):924-8.
RGD ID: 634184
Pubmed: PMID:11741278   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.5932   (Journal Full-text)

The treatment of Alzheimer's disease (AD) remains a major challenge because of the incomplete understanding of the triggering events that lead to the selective neurodegeneration characteristic of AD brains. Here we describe a new transcript of synaptic vesicle protein 2B (SV2Bb) mRNA that is up-regulated at mRNA level in neurons by amyloid beta peptide (Abeta) fragment (1-42). In comparison to SV2B this new mRNA encodes for the same protein but it has an elongated 3'-untranslated region (3'UTR) that contains several AU-rich (AUR) cis-acting elements which are probably involved in posttranscriptional regulating of SV2Bb translation. In conclusion, alteration of SV2B(b) expression appears to be involved in processes of neuronal degeneration.

Objects referenced in this article
Gene Sv2b synaptic vesicle glycoprotein 2b Rattus norvegicus

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