RGD Reference Report - Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization. - Rat Genome Database

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Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization.

Authors: Wagenfeld, A  Gromoll, J  Cooper, TG 
Citation: Wagenfeld A, etal., Biochem Biophys Res Commun 1998 Oct 20;251(2):545-9.
RGD ID: 634119
Pubmed: PMID:9792810   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.9512   (Journal Full-text)

Epididymal fluid from rats rendered infertile by oral administration of ornidazole contains a protein CAP1 (contraception-associated protein 1) that is absent from epididymal fluid, but present on epididymal sperm, from fertile vehicle-treated rats. The gene for CAP1 has been isolated from a rat testis cDNA library and its expression investigated in different tissues. The deduced protein sequence of CAP1 contains 189 amino-acid residues and database searches revealed a high degree of homology (83-95%) with human and mouse DJ-1 at the nucleotide and amino acid levels. Northern blot hybridisation from different rat tissues indicated that CAP1 is encoded by a 1.6-kilobase RNA transcript and seems to be ubiquitiously expressed in the rat with a high level of expression in the testis.

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