RGD Reference Report - Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. - Rat Genome Database

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Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate.

Authors: Nishio, T  Adachi, H  Nakagomi, R  Tokui, T  Sato, E  Tanemoto, M  Fujiwara, K  Okabe, M  Onogawa, T  Suzuki, T  Nakai, D  Shiiba, K  Suzuki, M  Ohtani, H  Kondo, Y  Unno, M  Ito, S  Iinuma, K  Nunoki, K  Matsuno, S  Abe, T 
Citation: Nishio T, etal., Biochem Biophys Res Commun 2000 Sep 7;275(3):831-8.
RGD ID: 634098
Pubmed: PMID:10973807   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2000.3377   (Journal Full-text)

We have isolated a rat novel multispecific organic anion transporter, moat1. The isolated clones were originated by alternative splicing of the moat1 mRNA. The nucleotide sequences predict a protein of 682 amino acids with moderate sequence similarity to LST-1, the oatp family, and the prostaglandin transporter. Northern blot analysis of rat moat1 identified a predominant transcript of 4.4 kilonucleotides in all tissues. Northern blot and in situ hybridization analyses of rat brain further indicated that moat1 mRNA is widely distributed in neuronal cells of the central nervous system, especially in the hippocampus and cerebellum. moat1 transports prostaglandin D(2) (K(m); 35.5 nM), leukotriene C(4) (K(m); 3.2 microM) and taurocholate (K(m); 17.6 microM) in a sodium-independent manner. moat1 also transports prostaglandin E(1), E(2), thromboxane B(2), and iloprost but not dehydroepiandrosterone sulfate and digoxin, of which the substrate specificity is similar, but definitively different from those of any other organic anion transporters.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
organic anion transmembrane transporter activity enablesIDA 634098PMID:10973807UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slco2b1  (solute carrier organic anion transporter family, member 2b1)


Additional Information