RGD Reference Report - MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters. - Rat Genome Database

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MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.

Authors: Deverson, EV  Gow, IR  Coadwell, WJ  Monaco, JJ  Butcher, GW  Howard, JC 
Citation: Deverson EV, etal., Nature 1990 Dec 20-27;348(6303):738-41.
RGD ID: 634072
Pubmed: PMID:1979660   (View Abstract at PubMed)
DOI: DOI:10.1038/348738a0   (Journal Full-text)

The T-cell immune response is directed against antigenic peptide fragments generated in intracellular compartments, the cytosol or the endocytic system. Peptides derived from cytosolic proteins, usually of biosynthetic origin, are presented efficiently to T-cell receptors by major histocompatibility complex (MHC) class I molecules, with which they assemble, probably in the endoplasmic reticulum (ER). In the absence of recognizable N-terminal signal sequences, such cytosolic peptides must be translocated across the ER membrane by a novel mechanism. Genes apparently involved in the normal assembly and transport of class I molecules may themselves be encoded in the MHC. Here we show that one of these, the rat cim gene, maps to a highly polymorphic part of the MHC class II region encoding two novel members of the family of transmembrane transporters related to multidrug resistance. Other members of this family of transporter proteins are known to be capable of transporting proteins and peptides across membranes independently of the classical secretory pathway. Such molecules are credible candidates for peptide pumps that move fragments of antigenic proteins from the cytosol into the ER.

Objects referenced in this article
Gene H2-Ob histocompatibility 2, O region beta locus Mus musculus
Gene Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Mus musculus
Gene Tap1 transporter 1, ATP binding cassette subfamily B member Rattus norvegicus

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