RGD Reference Report - Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules. - Rat Genome Database

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Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules.

Authors: Taketomi, M  Kinoshita, N  Kimura, K  Kitada, M  Noda, T  Asou, H  Nakamura, T  Ide, C 
Citation: Taketomi M, etal., Neurosci Lett 2002 Oct 25;332(1):37-40.
RGD ID: 633935
Pubmed: PMID:12377379   (View Abstract at PubMed)

Nogo-A is known as an oligodendrocyte/myelin-associated molecule having an inhibitory effect on neurite outgrowth in the central nervous system. During development, starting from P21 Nogo-A was detected in the cytoplasm of mature oligodendrocytes with compact myelin sheaths in the rat spinal cord. COS7 cells transfected with recNogo-A displayed strong Nogo-A immunoreactivity in their cytoplasm as well as on the mitotic spindle. Nogo-A was not detected in membrane protein fractions from transfected plus biotinylated COS7 cells. Nogo-A was co-immunoprecipitated with alpha-tubulin and myelin basic protein (MBP) from rat brain tissue. These results show that Nogo-A is expressed in association with tubulin and MBP in the mature oligodendrocytes.

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Gene Rtn4 reticulon 4 Rattus norvegicus

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