RGD Reference Report - Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor. - Rat Genome Database

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Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor.

Authors: Chittka, A  Chao, MV 
Citation: Chittka A and Chao MV, Proc Natl Acad Sci U S A 1999 Sep 14;96(19):10705-10.
RGD ID: 633619
Pubmed: PMID:10485890   (View Abstract at PubMed)
PMCID: PMC17947   (View Article at PubMed Central)

A subclass of zinc finger proteins containing a unique protein motif called the positive regulatory (PR) domain has been described. The members include the PRDI-BF1/Blimp-1 protein, the Caenorhabditis elegans egl-43 and EVI1 gene products, and the retinoblastoma interacting protein RIZ. Here we describe a member of this family, SC-1, that exhibits several distinctive features. First, SC-1 interacts with the p75 neurotrophin receptor and is redistributed from the cytoplasm to the nucleus after nerve growth factor (NGF) treatment of transfected COS cells. The translocation of SC-1 to the nucleus was specific for p75, as NGF binding to the TrkA receptor did not lead to nuclear localization of SC-1. Thus, SC-1 provides a downstream transducer for the effects of NGF through the p75 neurotrophin receptor. Under normal growth conditions, SC-1 was found predominantly in the cytoplasm. On serum-starvation, SC-1 also translocated into the nucleus. A direct correlation between nuclear expression of SC-1 with the loss of BrdUrd incorporation was observed. These results imply that SC-1 may be involved in events associated with growth arrest.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to growth factor stimulus  IEP 633619nerve growth factorRGD 
cellular response to nutrient  IEP 633619fetal calf serumRGD 
negative regulation of cell growth  IDA 633619 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
death receptor binding  IPINgfr (Rattus norvegicus)633619 RGD 
protein binding  IPIPrdm4 (Rattus norvegicus)633619 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngfr  (nerve growth factor receptor)
Prdm4  (PR/SET domain 4)


Additional Information