RGD Reference Report - An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors. - Rat Genome Database

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An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors.

Authors: Masuda, N  Yasumo, H  Tamura, T  Hashiguchi, N  Furusawa, T  Tsukamoto, T  Sadano, H  Osumi, T 
Citation: Masuda N, etal., Biochim Biophys Acta 1997 Jan 3;1350(1):27-32.
RGD ID: 633448
Pubmed: PMID:9003453   (View Abstract at PubMed)

The yeast two-hybrid screening was applied to cloning cDNAs of proteins that interact with peroxisome proliferator-activated receptor alpha (PPAR alpha). We obtained from a rat liver cDNA library a clone encoding a protein related to the ligand-binding domain of the members of nuclear hormone receptor superfamily, whereas apparently lacking the zinc-finger DNA-binding domain. This protein interacted with the activated forms of several nuclear receptors, and thus is a novel type of heterodimer-forming nuclear receptor.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Nr0b2  (nuclear receptor subfamily 0, group B, member 2)


Additional Information