RGD Reference Report - A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation. - Rat Genome Database

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A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation.

Authors: Misra-Press, A  Rim, CS  Yao, H  Roberson, MS  Stork, PJ 
Citation: Misra-Press A, etal., J Biol Chem 1995 Jun 16;270(24):14587-96.
RGD ID: 633293
Pubmed: PMID:7782322   (View Abstract at PubMed)

Mitogen-activated protein (MAP) kinase lies at the convergence of various extracellular ligand-mediated signaling pathways. It is activated by the dual-specificity kinase, MAP kinase kinase or MEK. MAP kinase inactivation is mediated by dephosphorylation via specific MAP kinase phosphatases (MKPs). One MKP (MKP-1 (also known as 3CH134, Erp, or CL100)) has been reported to be expressed in a wide range of tissues and cells. We report the identification of a second widely expressed MKP, termed MKP-2, isolated from PC12 cells. MKP-2 showed significant homology with MKP-1 (58.8% at the amino acid level) and, like MKP-1, displayed vanadate-sensitive phosphatase activity against MAP kinase in vitro. Overexpression of MKP-2 in vivo inhibited MAP kinase-dependent gene transcription in PC12 cells. MKP-2 differed from MKP-1 in its tissue distribution and in its extent of induction by growth factors and agents that induce cellular stress, suggesting that these MKPs may have distinct physiological functions.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
MAP kinase tyrosine/serine/threonine phosphatase activity  IDA 633293 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dusp4  (dual specificity phosphatase 4)


Additional Information