RGD Reference Report - The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. - Rat Genome Database

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The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.

Authors: Wang, Z  Tseng, CP  Pong, RC  Chen, H  McConnell, JD  Navone, N  Hsieh, JT 
Citation: Wang Z, etal., J Biol Chem 2002 Apr 12;277(15):12622-31.
RGD ID: 632628
Pubmed: PMID:11812785   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M110568200   (Journal Full-text)

DOC-2/DAB2 is a member of the disable gene family with tumor-inhibitory activity. Its down-regulation is associated with several neoplasms, and serine phosphorylation of its N terminus modulates DOC-2/DAB2's inhibitory effect on AP-1 transcriptional activity. We describe the cloning of DIP1/2, a novel gene that interacts with the N-terminal domain of DOC-2/DAB2. DIP1/2 is a novel GTPase-activating protein containing a Ras GTPase-activating protein homology domain (N terminus) and two other unique domains (i.e. 10 proline repeats and leucine zipper). Interaction between DOC-2/DAB2 and DIP1/2 is detected in normal tissues such as the brain and prostate. Altered expression of these two proteins is often detected in prostate cancer cells. Indeed, the presence of DIP1/2 effectively blocks mitogen-induced gene expression and inhibits the growth of prostate cancer. Thus, DOC-2/DAB2 and DIP1/2 appear to represent a unique negative regulatory complex that maintains cell homeostasis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GTPase activator activity  IDA 632628 RGD 
protein binding  IPIDab2ip (Rattus norvegicus)632628 RGD 
protein binding  IPIDab2 (Rattus norvegicus)632628 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dab2  (DAB adaptor protein 2)
Dab2ip  (DAB2 interacting protein)

Objects referenced in this article
Gene DAB2IP DAB2 interacting protein Homo sapiens

Additional Information