RGD Reference Report - CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase. - Rat Genome Database

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CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase.

Authors: Yap, CC  Liang, F  Yamazaki, Y  Muto, Y  Kishida, H  Hayashida, T  Hashikawa, T  Yano, R 
Citation: Yap CC, etal., J Neurochem 2003 Apr;85(1):123-34.
RGD ID: 632479
Pubmed: PMID:12641734   (View Abstract at PubMed)

Receptors and various molecules in neurons are localized at precise locations to perform their respective functions, especially in synaptic sites. Among synaptic molecules, PDZ domain proteins play major roles in scaffolding and anchoring membrane proteins for efficient synaptic transmission. In the present study, we isolated CIP98, a novel protein (98 kDa) consisting of three PDZ domains and a proline-rich region, which is widely expressed in the central nervous system. In situ hybridization and immunohistochemical staining patterns demonstrate that CIP98 is expressed strongly in certain types of neurons, i.e. pyramidal cells in layers III-V of the cerebral cortex, projecting neurons in the thalamus and interneurons in the cerebellum. The results of immunocytochemical staining and electron microscopy revealed that CIP98 is localized both in dendrites and axons. Interestingly, CIP98 interacts with CASK (calmodulin-dependent serine kinase), a member of the membrane-associated guanylate kinase (MAGUK) family that plays important roles in the molecular organization of proteins at synapses. CIP98 was shown to co-localize with CASK along the dendritic processes of neurons. In view of its direct association with CASK, CIP98 may be involved in the formation of CASK scaffolding proteins complex to facilitate synaptic transmission in the CNS.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
apical dendrite  IDA 632479 RGD 
axon collateral  IDA 632479 RGD 
dendrite  IDA 632479 RGD 
dendritic shaft  IDA 632479 RGD 
neuronal cell body  IDA 632479 RGD 
perinuclear region of cytoplasm  IDA 632479; 632479 RGD 
postsynapse  IDA 632479 RGD 
presynapse  IDA 632479 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
PDZ domain binding  IPIWhrn (Rattus norvegicus)632479 RGD 
protein domain specific binding  IPICask (Rattus norvegicus)632479 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cask  (calcium/calmodulin dependent serine protein kinase)
Whrn  (whirlin)


Additional Information