RGD Reference Report - Mammalian BarH homologue is a potential regulator of neural bHLH genes. - Rat Genome Database

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Mammalian BarH homologue is a potential regulator of neural bHLH genes.

Authors: Saito, T  Sawamoto, K  Okano, H  Anderson, DJ  Mikoshiba, K 
Citation: Saito T, etal., Dev Biol 1998 Jul 15;199(2):216-25.
RGD ID: 632026
Pubmed: PMID:9698441   (View Abstract at PubMed)
DOI: DOI:10.1006/dbio.1998.8889   (Journal Full-text)

Vertebrate neurogenesis involves sequential actions of transcription factors. neurogenins, encoding Atonal-related bHLH transcription factors, function as neuronal determination genes in Xenopus. neurogenins and antother bHLH factor gene, Mash1, are expressed in distinct subsets or areas of cells giving rise to neurons, suggesting that these genes play important roles to generate distinct populations of neurons. A mammalian homologue of BarH (MBH1) is expressed in a complementary pattern to Mash1 expression in the developing nervous system like neurogenins. Forced expression of MBH1 down-regulates expression of Mash1 and up-regulates neurogenin2/Math4A, a member of neurogenins, in P19 cells during neuronal differentiation. This suggests that MBH1 is a potential regulator of mammalian neural bHLH genes, thereby establishing distinct pathways of neuronal differentiation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nervous system development  IDA 632026 RGD 
regulation of neuron differentiation  TAS 632026 RGD 
regulation of transcription by RNA polymerase II  IDA 632026 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DNA-binding transcription factor activity  IDA 632026 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Barhl2  (BarH-like homeobox 2)


Additional Information