RGD Reference Report - AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis. - Rat Genome Database

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AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.

Authors: Page, G  Lodige, I  Kogel, D  Scheidtmann, KH 
Citation: Page G, etal., FEBS Lett 1999 Nov 26;462(1-2):187-91.
RGD ID: 631947
Pubmed: PMID:10580117   (View Abstract at PubMed)

Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb mRNA seems to be ubiquitously expressed. AATF contains an extremely acidic domain and a putative leucine zipper characteristic of transcription factors. Indeed, a Gal4-BD-AATF fusion protein exhibited strong transactivation activity. Interestingly, AATF interfered with Dlk-induced apoptosis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of apoptotic process  IDA 631947 RGD 
positive regulation of DNA-templated transcription  IDA 631947 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein kinase binding  IPIDapk3 (Rattus norvegicus)631947 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aatf  (apoptosis antagonizing transcription factor)

Objects referenced in this article
Gene Dapk3 death-associated protein kinase 3 Rattus norvegicus
Gene Mapt microtubule-associated protein tau Rattus norvegicus

Additional Information