RGD Reference Report - Fine linkage mapping of the blood pressure quantitative trait locus region on rat chromosome 1. - Rat Genome Database

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Fine linkage mapping of the blood pressure quantitative trait locus region on rat chromosome 1.

Authors: Cui, ZH  Nemoto, K  Kawakami, K  Gonda, T  Nabika, T  Masuda, J 
Citation: Cui ZH, etal., Hypertens Res 2002 Jul;25(4):605-8.
RGD ID: 631321
Pubmed: PMID:12358148   (View Abstract at PubMed)

To narrow the area known to contain the blood pressure quantitative trait locus (QTL) on rat chromosome 1, we constructed a fine linkage map covering the blood pressure OTL region on the chromosome using 22 genetic markers informative for stroke-prone spontaneously hypertensive rats of the Izumo colony (SHRSP/Izm) and Wistar-Kyoto rats of the Izumo colony (WKY/Izm). Linkage mapping was done by genotyping 626 backcrossed rats from matings between SHRSP/Izm and WKY/Izm. Nineteen genetic markers informative for the two strains were selected from public databases. Two markers were newly isolated by screening a rat genomic library. One marker was mapped using a restriction endonuclease polymorphism. The region between DlWox29 and D1Smu11 was covered with 22 informative markers placed every 0.6 cM on average. In addition, 6 physiological candidates for a hypertension gene were mapped in this region either by linkage or by radiation hybrid (RH) mapping. This information should be essential for the construction and analysis of congenic strains for this QTL region.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IDA 631321 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased systemic arterial blood pressure  QTM 631321 RGD 
Objects Annotated

QTLs
Bp138  (Blood pressure QTL 138)

Strains
SHRSP/Izm  (NA)
WKY/Izm  (Wistar-Kyoto)

Objects referenced in this article
Marker D1Smu12 D1Smu12 Rattus norvegicus
Marker D1Smu13 D1Smu13 Rattus norvegicus

Additional Information