RGD Reference Report - Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats. - Rat Genome Database

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Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.

Authors: Yamasaki, Y  Watanabe, TK  Okuno, S  Ono, T  Oga, K  Mizoguchi-Miyakita, A  Goto, Y  Shinomiya, H  Momota, H  Miyao, H  Hayashi, I  Asai, T  Suzuki, M  Harada, Y  Hishigaki, H  Wakitani, S  Takagi, T  Nakamura, Y  Tanigami, A 
Citation: Yamasaki Y, etal., Clin Exp Pharmacol Physiol 2000 Nov;27(11):881-6.
RGD ID: 619669
Pubmed: PMID:11071303   (View Abstract at PubMed)

1. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a model of type II diabetes with accompanying dyslipidaemia and obesity. 2. To define chromosomal intervals associated with obesity (abdominal fat weight and plasma leptin levels), dyslipidaemia (plasma triglyceride, cholesterol and free fatty acids) and hyperglycaemia (plasma glucose levels), we have performed genome-wide quantitative traits loci (QTL) analyses of 115 male OLETF x (OLETF x Fischer 344) backcross animals at 16 weeks of age. 3. The Diabetes Mellitus OLETF type I (Dmo1) locus on rat chromosome 1 showed statistically significant involvement in elevations of plasma levels of triglycerides (P = 4.87 x 10(-6) at D1Rat90) and total cholesterol (P = 1.16 x 10(-5) at D1Rat306). 4. No other loci produced significant linkage to these observed phenotypes. 5. These analyses have confirmed the importance of Dmo1 in lipid homeostasis at younger ages as well as during overt diabetes, which appears later. Thus, alterations at the Dmo1 locus are a major risk factor for pathogenesis in the strain, a finding that agrees with physiological studies that indicate a role for dyslipidaemia in the type II diabetic syndrome of OLETF rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypercholesterolemia  IDA 619669 RGD 
Hypertriglyceridemia  IDA 619669 RGD 
obesity  IDA 619669 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased circulating cholesterol level  QTM 619669; 619669 RGD 
increased circulating triglyceride level  QTM 619669 RGD 
increased total body fat amount  IDA 619669 RGD 

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Objects Annotated

QTLs
Bw116  (Body weight QTL 116)
Scl67  (Serum cholesterol level QTL 67)
Stl31  (Serum triglyceride level QTL 31)

Strains
BN/SsNHsd  (NA)
OLETF.F344-(D1Rat169-D1Rat459)/Got  (NA)
OLETF/Got  (Otsuka Long Evans Tokushima)

Objects referenced in this article
QTL Bw115 Body weight QTL 115 Rattus norvegicus
QTL Niddm45 Non-insulin dependent diabetes mellitus QTL 45 Rattus norvegicus

Additional Information