RGD Reference Report - Genetic mapping of quantitative trait loci influencing left ventricular mass in rats. - Rat Genome Database

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Genetic mapping of quantitative trait loci influencing left ventricular mass in rats.

Authors: Tsujita, Y  Iwai, N  Tamaki, S  Nakamura, Y  Nishimura, M  Kinoshita, M 
Citation: Tsujita Y, etal., Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2062-7.
RGD ID: 619658
Pubmed: PMID:11045938   (View Abstract at PubMed)

High blood pressure is the leading cause of left ventricular hypertrophy (LVH); however, not all hypertensive patients develop LVH. Genetic factors are important in the development of LVH. With the use of F2 male rats from spontaneously hypertensive rats and Lewis rats, we performed a study to identify the quantitative trait loci (QTL) that influence left ventricular mass (LVM). Mean arterial pressure (MAP) was measured by the direct intra-arterial method in conscious animals, and LVM was determined at 24 wk of age. QTL analysis was done using 160 microsatellite markers for a genome-wide scan. Two loci that influenced body weight-adjusted LVM with logarithm of the odds scores >3.4 were found. One locus on chromosome 17 influenced LVM independently of MAP. Another locus on chromosome 7 influenced LVM and MAP. These findings indicate not only the existence of a gene on chromosome 7 that influences LVM in a manner dependent on blood pressure but also the existence of a gene on chromosome 17 that influences LVM independently of blood pressure.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IDA 619658 RGD 
hypertension MODEL: spontaneousIAGP 619658compared to LEW/CrlCrlj strainRGD 
Left Ventricular Hypertrophy  IDA 619658; 619658 RGD 
Left Ventricular Hypertrophy MODEL: spontaneousIAGP 619658compared to LEW/CrlCrlj strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased heart left ventricle weight  IAGP 619658compared to SHR/IzmRGD 
decreased mean systemic arterial blood pressure  IAGP 619658compared to SHR/IzmRGD 
heart left ventricle hypertrophy  IAGP 619658; 619658 RGD 
heart left ventricle hypertrophy  IAGP 619658compared to LEW/CrlCrlj strainRGD 
increased body weight  IAGP 619658compared to SHR/IzmRGD 
increased systemic arterial blood pressure  IAGP 619658 RGD 
increased systemic arterial blood pressure  IAGP 619658compared to LEW/CrlCrlj strainRGD 

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Objects Annotated

QTLs
Cm26  (Cardiac mass QTL 26)
Cm27  (Cardiac mass QTL 27)

Strains
LEW/CrlCrlj  (NA)
SHR/Izm  (NA)


Additional Information