RGD Reference Report - Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. - Rat Genome Database

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Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing.

Authors: Kim, J  Jones, BW  Zock, C  Chen, Z  Wang, H  Goodman, CS  Anderson, DJ 
Citation: Kim J, etal., Proc Natl Acad Sci U S A 1998 Oct 13;95(21):12364-9.
RGD ID: 61603
Web Url: http://www.pnas.org/cgi/content/full/95/21/12364
Pubmed: PMID:9770492   (View Abstract at PubMed)
PMCID: PMC22837   (View Article at PubMed Central)

The glial cells missing (gcm) gene in Drosophila encodes a transcription factor that determines the choice between glial and neuronal fates. We report here the isolation of two mammalian gcm homologs, Gcm1 and Gcm2, and the characterization of their expression patterns during embryonic development. Although Gcm2 is expressed in neural tissues at a low level, the major sites of expression for both of the mammalian genes are nonneural, suggesting that the functions of the mammalian homologs have diverged and diversified. However, when expressed ectopically, Gcm1 can substitute functionally for Drosophila gcm by transforming presumptive neurons into glia. Thus, certain biochemical properties, although not the specificity of the tissue in which the gene is expressed, have been conserved through the evolution of the Gcm gene family.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of DNA-templated transcription  TAS 61603 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DNA-binding transcription factor activity  TAS 61603 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gcm1  (glial cells missing transcription factor 1)

Objects referenced in this article
Gene Gcm1 glial cells missing homolog 1 Mus musculus
Gene Gcm2 glial cells missing homolog 2 Mus musculus
Gene Pth parathyroid hormone Mus musculus

Additional Information