RGD Reference Report - Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension. - Rat Genome Database

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Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension.

Authors: Innes, BA  McLaughlin, MG  Kapuscinski, MK  Jacob, HJ  Harrap, SB 
Citation: Innes BA, etal., Hypertension 1998 Mar;31(3):741-6
RGD ID: 61484
Web Url: http://hyper.ahajournals.org/cgi/content/full/31/3/741
Pubmed: PMID:9495256   (View Abstract at PubMed)

Cardiac hypertrophy is a common but not inevitable complication of hypertension. Variation in heart size in hypertensives may reflect independent genetic susceptibility to cardiac hypertrophy. Using an experimental genetic model, we determined the location of quantitative trait loci responsible for cardiac hypertrophy and/or hypertension. We studied 182 F2 male animals derived from a cross of the spontaneously hypertensive rat and normotensive Donryu rats. Direct mean arterial pressure (MAP) and left ventricular (LV) mass were measured at 20 weeks of age, and DNA was obtained for linkage analysis. The estimated heritability of MAP was 62% and for LV mass expressed per unit of body weight (relative LV mass) was 76%. We used 185 polymorphic markers, with an average intermarker distance of 12.3 centimorgans for a genome-wide scan in a representative subgroup of 46 animals to identify preliminary quantitative trait loci, which were then mapped in all 182 male F2 rats. Two loci showed logarithm of the odds scores of > 4.0. One on chromosome 2, Lvm-1, was linked to relative LV mass but showed no evidence of linkage to MAP. Another locus on chromosome 1, Map-1, was linked to MAP. In the same region, a locus Lvm-2 was linked with relative LV mass. These data indicate the existence of a genetic locus on chromosome 2 of the spontaneously hypertensive rat that affects relative LV mass independently of blood pressure.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IDA 61484 RGD 
hypertension MODEL: controlIAGP 61484compared to SHR/N strainRGD 
hypertension MODEL: spontaneousIAGP 61484compared to DRY control strainRGD 
Left Ventricular Hypertrophy  IDA 61484; 61484 RGD 
Left Ventricular Hypertrophy  IAGP 61484compared to DRY control strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
heart left ventricle hypertrophy  IAGP 61484; 61484 RGD 
heart left ventricle hypertrophy  IAGP 61484compared to DRY control strainRGD 
increased mean systemic arterial blood pressure  IAGP 61484compared to DRY control strainRGD 
increased systemic arterial blood pressure  IAGP 61484 RGD 

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Objects Annotated

QTLs
Bp196  (Blood pressure QTL 196)
Cm22  (Cardiac mass QTL 22)
Cm23  (Cardiac mass QTL 23)

Strains
DRY  (NA)
SHR/N  (NA)

Objects referenced in this article
QTL Cm25 Cardiac mass QTL 25 Rattus norvegicus

Additional Information