Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

Authors: Galli, J  Li, LS  Glaser, A  Ostenson, CG  Jiao, H  Fakhrai-Rad, H  Jacob, HJ  Lander, ES  Luthman, H 
Citation: Galli J, etal., Nat Genet 1996 Jan;12(1):31-7
Pubmed: (View Article at PubMed) PMID:8528247
DOI: Full-text: DOI:10.1038/ng0196-31

Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.

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