RGD Reference Report - Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients. - Rat Genome Database

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Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients.

Authors: Sobti, RC  Berhane, N  Mahdi, SA  Kler, R  Hosseini, SA  Kuttiat, V  Wanchu, A 
Citation: Sobti RC, etal., Mol Biol Rep. 2011 Jun;38(5):2945-52. Epub 2010 Feb 2.
RGD ID: 5688740
Pubmed: PMID:20127180   (View Abstract at PubMed)
DOI: DOI:10.1007/s11033-010-9958-8   (Journal Full-text)

HIV/AIDS remains to be one of the killing diseases of mankind. Host genetic response is one of the factor which determine susceptibility to HIV and disease progression to AIDS. The aim of the present study was to evaluate the impact of ERCC2 Lyc ( 751 ) Gln (excision repair cross complementing rodent repair deficiency, complementation group 2) polymorphism on HIV-1 susceptibility and disease progression to AIDS, as this gene has been reported to intervene in degrading retroviral cDNA before it integrates with the host DNA. This case control study included 300 HIV seropositive cases and an equal number of HIV seronegative controls. DNA was isolated from the blood samples of study subjects and genotyping of ERCC2 was conducted by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. The Gln/Gln genotype showed a significant variation between cases and controls (P = 0.047, OR 1.71, 95% CI 1.00-2.93), indicating a possible role of susceptibility in reference to controls and disease progression when compared within cases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acquired immunodeficiency syndrome susceptibilityIAGP 5688740DNA:polymorphism:exon:p.K751Q(human)RGD 
acquired immunodeficiency syndrome susceptibilityISOERCC2 (Homo sapiens)5688740; 5688740DNA:polymorphism:exon:p.K751Q(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ercc2  (ERCC excision repair 2, TFIIH core complex helicase subunit)

Genes (Mus musculus)
Ercc2  (excision repair cross-complementing rodent repair deficiency, complementation group 2)

Genes (Homo sapiens)
ERCC2  (ERCC excision repair 2, TFIIH core complex helicase subunit)


Additional Information