RGD Reference Report - Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats. - Rat Genome Database

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Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats.

Authors: Harada, N  Taoka, Y  Okajima, K 
Citation: Harada N, etal., J Neurotrauma. 2006 Dec;23(12):1739-49.
RGD ID: 5688221
Pubmed: PMID:17184185   (View Abstract at PubMed)
DOI: DOI:10.1089/neu.2006.23.1739   (Journal Full-text)

We investigated the role of prostacyclin (PGI(2)) in the development of compression trauma-induced spinal cord injury (SCI) in rats. When measured after induction of SCI, tissue levels of 6-keto-PGF(1), a stable PGI(2) metabolite, thromboxane B(2) (TXB(2)), a stable metabolite of thromboxane A(2), myeloperoxidase (MPO) activity, and tumor necrosis factor (TNF) in the injured spinal cord segment were significantly increased, peaking at 2, 3, and 4 h after induction of SCI, respectively. Subcutaneous administration of indomethacin (IM), a non-selective cyclooxygenase (COX) inhibitor, completely inhibited increases in tissue levels of 6-keto-PGF(1) and TXB(2), while administration of NS-398, a selective inhibitor of COX-2, did not affect these increases. Although pretreatment with IM enhanced increases in tissue levels of MPO, TNF, and TNF mRNA and exacerbated both motor disturbances and histological damage in the spinal cord of animals subjected to SCI, pretreatment with NS-398 had no effect on any of these findings. Both iloprost, a stable analog of PGI(2), and leukocyte depletion significantly reversed changes in various variables and exacerbation of motor disturbances induced by IM pretreatment in animals subjected to SCI. These observations strongly suggested that compression trauma-induced increase in PGI(2) production in spinal cord tissue might be mainly mediated by COX-1 and PGI(2) might play a critical role in reduction of motor disturbances following SCI by inhibiting neutrophil accumulation through inhibition of TNF production.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spinal Cord Injuries  ISOPtgs1 (Rattus norvegicus)5688221; 5688221 RGD 
Spinal Cord Injuries  IMP 5688221 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)

Genes (Mus musculus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)

Genes (Homo sapiens)
PTGS1  (prostaglandin-endoperoxide synthase 1)


Additional Information