RGD Reference Report - Reduced density of dopamine D2-like receptors on peripheral blood lymphocytes in Alzheimer's disease. - Rat Genome Database

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Reduced density of dopamine D2-like receptors on peripheral blood lymphocytes in Alzheimer's disease.

Authors: Barbanti, P  Fabbrini, G  Ricci, A  Bruno, G  Cerbo, R  Bronzetti, E  Amenta, F  Luigi Lenzi, G 
Citation: Barbanti P, etal., Mech Ageing Dev. 2000 Dec 1;120(1-3):65-75.
RGD ID: 5686416
Pubmed: PMID:11087905   (View Abstract at PubMed)

Clinical and pathological evidence points to an involvement of dopamine in Alzheimer's disease (AD). The present study was designed to assay dopamine D1-like and D2-like receptors on peripheral blood lymphocytes (PBL) in 20 patients with AD and in 25 healthy controls by radioligand binding assay techniques with [3H][R]-(+)-(-)chloro-2,3,4,5 tetrahydro-5-phenyl-1H-3-benzazepin-al-hemimaleate (SCH 23390) and [3H]7-hydroxy-N,N-di-n-propyl-2-aminotetraline (7OH-DPAT) as radioligands. The density of dopamine D1-like receptors and the affinity of [3H]SCH 23390 and [3H]7OH-DPAT binding to PBL were similar in both groups investigated. AD patients revealed a lower density of dopamine D2-like receptors on PBL than controls (P=0. 0016). The pharmacological profile of [3H]SCH 23390 and [3H]7OH-DPAT binding to PBL was consistent with the labeling of dopamine D5 and D3 receptor subtypes, respectively. The reduced density of dopamine D2-like receptors on PBL is consistent with the observation of changes in the expression of D2-like receptors in dopaminergic brain areas in AD. Our findings support the hypothesis of an involvement of dopamine in AD, even in those patients with no evidence of Parkinsonism, behavioral abnormalities or psychosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 5686416protein:decreased expression:blood and lymphocyteRGD 
Alzheimer's disease  ISODRD2 (Homo sapiens)5686416; 5686416protein:decreased expression:blood and lymphocyteRGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)

Genes (Mus musculus)
Drd2  (dopamine receptor D2)

Genes (Homo sapiens)
DRD2  (dopamine receptor D2)


Additional Information