RGD Reference Report - Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain. - Rat Genome Database

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Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain.

Authors: Lappalainen, J  Lappalainen, Z  Oksala, NK  Laaksonen, DE  Khanna, S  Sen, CK  Atalay, M 
Citation: Lappalainen J, etal., Cell Biochem Funct. 2010 Dec 2;28(8):644-50. doi: 10.1002/cbf.1702. Epub 2010 Oct 29.
RGD ID: 5686396
Pubmed: PMID:21104931   (View Abstract at PubMed)
DOI: DOI:10.1002/cbf.1702   (Journal Full-text)

Heat shock proteins (HSPs) are molecular chaperones which may act protective in cerebrovascular insults and peripheral diabetic neuropathy. We hypothesized that alpha-lipoic acid (LA), a natural thiol antioxidant, may enhance brain HSP response in diabetes. Rats with or without streptozotocin-induced diabetes were treated with LA or saline for 8 weeks. Half of the rats were subjected to exhaustive exercise to investigate HSP induction, and the brain tissue was analyzed. Diabetes increased constitutive HSC70 mRNA, and decreased HSP90 and glucose-regulated protein 75 (GRP75) mRNA without affecting protein levels. Exercise increased HSP90 protein and mRNA, and also GRP75 and heme oxygenase-1 (HO-1) mRNA only in non-diabetic animals. LA had no significant effect on brain HSPs, although LA increased HSC70 and HO-1 mRNA in diabetic animals and decreased HSC70 mRNA in non-diabetic animals. Eukaryotic translation elongation factor-2, essential for protein synthesis, was decreased by diabetes and suggesting a mechanism for the impaired HSP response related to translocation of the nascent chain during protein synthesis. LA supplementation does not offset the adverse effects of diabetes on brain HSP mRNA expression. Diabetes may impair HSP translation through elongation factors related to nascent chain translocation and subsequent responses to acute stress.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOHsp90aa1 (Rattus norvegicus)5686396; 5686396mRNA:decreased expression:brain (rat)RGD 
Experimental Diabetes Mellitus  IEP 5686396mRNA:decreased expression:brain (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hsp90aa1  (heat shock protein 90 alpha family class A member 1)

Genes (Mus musculus)
Hsp90aa1  (heat shock protein 90, alpha (cytosolic), class A member 1)

Genes (Homo sapiens)
HSP90AA1  (heat shock protein 90 alpha family class A member 1)


Additional Information