RGD Reference Report - Adiponectin in outpatients with coronary artery disease: Independent predictors and relationship with heart failure. - Rat Genome Database

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Adiponectin in outpatients with coronary artery disease: Independent predictors and relationship with heart failure.

Authors: Baldasseroni, S  Mannucci, E  Orso, F  Di Serio, C  Pratesi, A  Bartoli, N  Marella, GA  Colombi, C  Foschini, A  Valoti, P  Mossello, E  Fumagalli, S  Marchionni, N  Tarantini, F 
Citation: Baldasseroni S, etal., Nutr Metab Cardiovasc Dis. 2011 Oct 25.
RGD ID: 5686388
Pubmed: PMID:22032915   (View Abstract at PubMed)
DOI: DOI:10.1016/j.numecd.2011.03.012   (Journal Full-text)

BACKGROUND AND AIMS: Chronic heart failure (HF) is characterised by a neurohormonal dysfunction associated with chronic inflammation. A role of metabolic derangement in the pathophysiology of HF has been recently reported. Adiponectin, an adipose-tissue-derived cytokine, seems to play an important role in cardiac dysfunction. We investigated the variation of circulating adiponectin in patients with coronary artery disease (CAD), with or without HF, in order to identify its independent predictors. METHODS AND RESULTS: A total of 107 outpatients with CAD were enrolled in the study and divided into three groups: CAD without left ventricular systolic dysfunction (group 1); CAD with left ventricular dysfunction without HF symptoms (group 2) and CAD with overt HF (group 3). Plasma adiponectin was determined by enzyme-linked immunosorbent assay. Adiponectin concentrations increased progressively from group 1 (7.6 +/- 3.6 ng ml(-1)) to group 2 (9.1 +/- 6.7 ng ml(-1)) and group 3 (13.7 +/- 7.6 ng ml(-1)), with the difference reaching statistical significance in group 3 versus 1 and 2 (p < 0.001). A multivariable model of analysis demonstrated that the best predictors of plasma adiponectin were body mass index, N-terminal pro-brain natriuretic peptide and high-density lipoprotein cholesterol. However, even after adjusting for all three independent predictors, the increase of adiponectin in group 3 still remained statistically significant (p = 0.015). CONCLUSION: Our data confirm the rise of adiponectin in overt HF. The levels of circulating adipokine seem to be mainly predicted by the metabolic profile of patients and by biohumoral indicators, rather than by clinical and echocardiographic indexes of HF severity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
congestive heart failure  IEP 5686388associated with cardiovascular disease and protein:increased expression:plasmaRGD 
congestive heart failure  ISOADIPOQ (Homo sapiens)5686388; 5686388associated with cardiovascular disease and protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information