RGD Reference Report - Increased levels of adipokines in bipolar disorder. - Rat Genome Database

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Increased levels of adipokines in bipolar disorder.

Authors: Barbosa, IG  Rocha, NP  Miranda, AS  Magalhaes, PV  Huguet, RB  Souza, LP  Kapczinski, F  Teixeira, AL 
Citation: Barbosa IG, etal., J Psychiatr Res. 2011 Dec 2.
RGD ID: 5686381
Pubmed: PMID:22137759   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jpsychires.2011.11.010   (Journal Full-text)

Bipolar disorder (BD) is associated with considerable higher chronic medical comorbidities, overweight and obesity. Adipokines are adipocyte-derived secretory factors which have functions in immune response and seem to be associated with both BD and overweight. The aim of this study was to evaluate the plasma levels of adipokines (adiponectin, resistin and leptin) and TNF-alpha and its receptors (sTNFR1 and sTNFR2) in BD overweight patients in comparison with overweight controls. Thirty euthymic BD type-I patients and thirty controls matched by age, gender and body-mass index (BMI) were assessed by Mini-International Neuropsychiatric Interview, Young Mania and Hamilton Depression rating scales (YMRS and HDRS, respectively). Plasma levels of adiponectin, resistin, leptin, TNF-alpha and its soluble receptors were measured by ELISA. BD patients presented increased plasma levels of adiponectin (p < 0.001), leptin (p < 0.001) and sTNFR1 (p = 0.01). Plasma levels of adipokines were not correlated neither with clinical parameters nor TNF-alpha, sTNFR1 and sTNFR2 plasma levels. This study provides further support to the hypothesis of the immune/inflammatory imbalance in BD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bipolar disorder  IEP 5686381protein:increased expression:plasmaRGD 
bipolar disorder  ISOADIPOQ (Homo sapiens)5686381; 5686381protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information