RGD Reference Report - Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults. - Rat Genome Database

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Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults.

Authors: Jokela, M  Raikkonen, K  Lehtimaki, T  Rontu, R  Keltikangas-Jarvinen, L 
Citation: Jokela M, etal., J Affect Disord. 2007 Jun;100(1-3):191-7. Epub 2006 Nov 28.
RGD ID: 5686354
Pubmed: PMID:17134762   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jad.2006.10.016   (Journal Full-text)

BACKGROUND: Tryptophan hydroxylases (TPHs) are involved in the biosynthesis of serotonin and are therefore candidate genes for psychiatric disorders, including depression. We examined whether the common 218 A > C and 779 A > C polymorphisms in the tryptophan hydroxylase 1 gene (TPH1) moderated the association between perceived social support and sub-clinical depressive symptoms in adults. METHODS: The subjects were a randomly selected subsample (n=341) of individuals participating in the Cardiovascular Risk in Young Finns study, who had data on social support on one assessment time and depressive symptoms on two assessment times. Social support was assessed on the Perceived Social Support Scale Revised (PSSS-R) and depressive symptoms on a modified version of the Beck's Depression Inventory (BDI). RESULTS: We found that low social support predicted depressive symptoms more strongly in individuals carrying A alleles of the TPH1 than in others. The interaction effect was observed in a cross-sectional analysis and when predicting depressive symptoms over a four-year period. LIMITATIONS: We did not have data on TPH2, which has recently been identified as the primary TPH isomorphism affecting serotonin synthesis in the brain. CONCLUSIONS: TPH1 gene may be involved in the development of depressive symptoms by moderating the impact of depressogenic social influences.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
depressive disorder  IAGP 5686354DNA:SNPs more ...RGD 
depressive disorder  ISOTPH1 (Homo sapiens)5686354; 5686354DNA:SNPs more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tph1  (tryptophan hydroxylase 1)

Genes (Mus musculus)
Tph1  (tryptophan hydroxylase 1)

Genes (Homo sapiens)
TPH1  (tryptophan hydroxylase 1)


Additional Information