RGD Reference Report - B-type natriuretic peptide pretreatment attenuates heart ischemia-reperfusion injury in rats. - Rat Genome Database

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B-type natriuretic peptide pretreatment attenuates heart ischemia-reperfusion injury in rats.

Authors: Ren, B  Wu, H  Yin, R  Xu, L  Jing, H  Li, M  Jiang, F  Wang, Z 
Citation: Ren B, etal., Transplant Proc. 2010 Dec;42(10):4496-8.
RGD ID: 5685663
Pubmed: PMID:21168723   (View Abstract at PubMed)
DOI: DOI:10.1016/j.transproceed.2010.09.163   (Journal Full-text)

BACKGROUND: Graft dysfunction following transplantation is due to ischemia-reperfusion (IR) injury. B-type natriuretic peptide (BNP) has been shown to attenuate ischemia-reperfusion (IR) injury in animals. We designed this experiment to evaluate the effects of BNP pretreatment on IR-induced heart injury. METHODS: A rat model of myocardial IR injury was established by ligating the left descending coronary artery for 30 minutes before a 2-hour reperfusion. We randomly divided 47 Sprague-Dawley rats into six groups: sham operation (n = 6), IR (n = 9), IR + BNP 0.001 mug/(kg.min; n = 8); IR + BNP 0.005 mug/(kg.min; n = 8); IR + BNP 0.01 mug/(kg.min; n = 8); and IR + BNP 0.03 mug/(kg.min; n = 8). During the processes, lead ECG was traced continuously to note arrhythmias caused by reperfusion. Serum levels of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) were measured at 2 hours after reperfusion. RESULTS: The BNP-treated animals showed a significantly reduced incidence of ventricular arrhythmias caused by reperfusion (P < .05). They showed a dosage-dependent marked decrease in levels of serum CK-MB and LDH compared with the IR only group (P < .05). CONCLUSIONS: BNP pretreatment protected the myocardium of rats against IR injury, in a dose-dependent manner.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Myocardial Reperfusion Injury  ISONppb (Rattus norvegicus)5685663; 5685663 RGD 
Myocardial Reperfusion Injury  IDA 5685663 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppb  (natriuretic peptide B)

Genes (Mus musculus)
Nppb  (natriuretic peptide type B)

Genes (Homo sapiens)
NPPB  (natriuretic peptide B)


Additional Information