Candidate biomarkers of chronic inflammatory demyelinating polyneuropathy (CIDP): proteome analysis of cerebrospinal fluid.

Authors: Tumani, H  Pfeifle, M  Lehmensiek, V  Rau, D  Mogel, H  Ludolph, AC  Brettschneider, J 
Citation: Tumani H, etal., J Neuroimmunol. 2009 Sep 29;214(1-2):109-12. Epub 2009 Jul 9.
Pubmed: (View Article at PubMed) PMID:19589605
DOI: Full-text: DOI:10.1016/j.jneuroim.2009.06.012

We aimed to identify disease-related biomarkers in CIDP. Using the two-dimensional difference in gel electrophoresis (2-D-DIGE), we compared CSF from patients with CIDP (n = 11) and controls (n = 11). Protein spots that showed a significant difference were further analyzed by MALDI-TOF mass spectrometry. We identified 10 proteins that were upregulated in CIDP (two transferrin isoforms, alpha-1 acid glycoprotein 1 precursor, apolipoprotein A IV, two haptoglobin isoforms, transthyretin (TTR), retinol binding protein and two isoforms of proapolipoprotein) and 1 protein that was downregulated (integrin beta 8). The pathophysiological role of these proteins remains to be clarified by further studies.

Annotation

Disease Annotations
RGD Objects Annotated

Additional Information

 
RGD Object Information
RGD ID: 5685648
Created: 2012-01-13
Species: All species
Last Modified: 2012-01-13
Status: ACTIVE